Teng CM, Lee LG, Ko SN, et al. View abstract. Celery seed contains compounds that may be beneficial in the treatment of gout. Almost 70% of older adults use them. Further studies are needed to confirm these results so, to play it safe, monitor your blood pressure if you are taking a celery supplement. Field evaluation of G10, a celery (Apium graveolens)-based topical repellent, against mosquitoes (Diptera: Culicidae) in Chiang Mai province, northern Thailand. 1995;61:18-21. J AOAC Int 2001;84(4):1135-1143. Objective: To evaluate the efficacy of a standardized extract of celery seed, 150 mg/d, supplying 85% 3-n-butylphthalide (3nB) in mild to moderate hypertensive View abstract. But more importantly, they contain components that induce apoptosis, which causes cancer cells to self-destruct (x). (2014). The results showed that beta-selinene demonstrated a wide variety of antioxidant and anti-inflammatory properties. Be sure to wear sunblock and protective clothing when spending time in the sun. 1996;135(2):334. Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery]. Bull.Acad.Natl.Med 1995;179(1):161-184. Celery seeds are a versatile spice. Iron deficiency is the most common micronutrient deficiency worldwide, but eating more iron-rich foods has been shown to lower your risk of deficiency and subsequent anemia (16, 17). Here's. Celery oil and celery seeds are LIKELY SAFE when taken by mouth in food amounts. In one animal study, researchers investigated the impact of luteolin on nitric oxide produced from uric acid. Levothyroxine is used for low thyroid function. However, herbs can have side effects and interact with other herbs, supplements, or medications. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. IMPORTANT: Celery seed and celery extract should be avoided by pregnant women. Celery seed is contraindicated in pregnancy, as it may have uterotonic activity and has been used traditionally as an emmenagogue.Ernst 2002, Khan 2009 Celery has also been used for its antigalactic properties.Duke 2002, Kolarovic 2010, Limited studies in rodents suggest increased testosterone and improved sperm count and motility with supplemental celery oil.Kooti 2017, Although celery seed extract exhibits CYP-450 (particularly CYP2D6) enzyme inhibitory activity,Nguyen 2014 limited data suggest that interactions are unlikely.Powanda 2015, Tang 2017, A case report exists in which a woman experienced a manic episode 48 hours after adding celery root extract (1,000 mg/day) to her major depressive disorder treatment regimen of venlafaxine (75 mg/day) and St. John's wort (600 mg/day). View abstract. J Midwifery Womens Health 2009;54:401-4. One common dietary intervention for gout is celery. 2008;56(11):3997-4003. When blood pressure is reduced, the chances of developing atherosclerosis, heart attack or stroke also drops. 1998;60:117-124. Last updated on May 23, 2022. Am Fam.Physician 1989;39(4):143-146. J Vector Ecol. This information should not be used to decide whether or not to take this product. Wild celery can refer to Vallisneria spiralis L., an aquatic perennial. Antioxidants are compounds that prevent cellular damage caused by molecules called free radicals. Celery seed oil contains bergapten, which plays a part in the plants natural defense system. In fact, they serve the same purpose as cranberries in treating bladder disorders, cysts and kidney problems (x). Advertisement references Celery seeds contain non-heme iron. Celery seed extract may also have antioxidant properties. A tablespoon of celery seed contains 17 percent of the recommended daily value of iron, which is a significant boost for at-risk groups or those looking to increase their hemoglobin levels. Celery juice might decrease how quickly the liver breaks down and removes aminopyrine. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Celery has shown promise as a natural therapy for these and other health issues in animal studies, but remains to be proven effective in humans. Parts of the celery plant, botanically known as Apium graveolens, have been used therapeutically for thousands of years. Equally important, celery seeds offer high nutritional value. You can easily add celery seeds to your diet by adding them to soups, side dishes, and even hot tea. Celery seed extract is most often J Toxicol.Clin Toxicol. Here are a few more ways to add celery seeds to your diet: Interestingly, some people use ground celery seed to make tea. Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family. Pharm Biol. DO NOT take celery seeds from a gardening packet. Furthermore, consuming celery seed extract with a balanced diet plan could help to manage overall cholesterol levels. (2017). If you buy through links on this page, we may earn a small commission Heres our process. Again, no side effects were noted other than the diuretic effect with no changes in the sodium and potassium balance. The celery seed extract appeared to be particularly helpful for sufferers of gout, as 3nB appears to lower the production of the uric acid that causes gout by inhibiting the enzyme xanthine oxidase. However, celery stalks do contain fiber, and some research suggests an increase in dietary fiber can reduce gout attacks. Here are 10 of the world's healthiest herbs and spices, supported by science. Ko FN, Huang TF, Teng CM. WebThe author also recommends celery seed tinctures to treat sharp headaches over the eye and temple area that last all night, and for throbbing aches in the temple. J Ethnopharmacol. Sarshar S, Sendker J, Qin X, et al. Combined with the high fiber content, celery seed extract can help maintain regularity and reduce bloating (x). For this reason, it is important to consult with your healthcare provider before taking supplemental celery seed. A report in a study, published in Pharmacognosy Review in June 2017, says large amounts of celery may lead to muscle contractions in the uterus and uterine bleeding, both of which could increase the risk of miscarriage. The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics. J.Emerg.Med. One tablespoon (6.5 grams) of celery seeds provides ( 2 Trusted Source ): 1 Calories: 25 calories 2 Carbs: 2 grams 3 Protein: 1 gram 4 Fat: 2 grams 5 Fiber: 1 gram 6 Calcium: 12% of the Reference Daily Intake (RDI) 7 Zinc: 6% of the RDI 8 Manganese: 27% of the RDI 9 Iron: 17% of the RDI 10 Magnesium: 9% of the RDI More items Nutr Cancer. In many countries, celery is harvested primarily for its seeds due to the medicinal properties they contain. Parmesan or Parmigiano-Reggiano is a hard Italian cheese. This may lead to a lower bone mineral density, which is a measure of the number of minerals present in a certain volume of bone (3, 4, 5). Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. As medicine, celery seed powder or extract have most often been used by adults in doses of 1000-1500 mg by Read more: 10 Facts You Need to Know About Food Allergies. These extracts have been standardized to contain certain percentages of beneficial compounds, such as luteolin or 3nB. This article tells you all you need to know about celeriac, Acid reflux or GERD can lead to some unpleasant symptoms, like heartburn, a sour taste in the mouth, and even difficulty swallowing. 2002;27(3):153-156. Using these products together might increase the risk of sunburn, blistering, or rashes when the skin is exposed to sunlight. Celery seed extracts exhibit CYP-450 (particularly CYP2D6) enzyme inhibitory activity. (2003). DOI: Dolati K, et al. We include products we think are useful for our readers. View abstract. Some medications are changed and broken down by the liver. If you want to try the celery seed powder, I'd In one trial, dl-3-n-butylphthalide 400 mg orally daily (given as one 200 mg capsule twice daily) as part of a 90-day treatment regimen was used to improve outcomes in patients with acute ischemic stroke. The dosage was found to increase sperm count in rats. DOI: Chandra M, et al. For example, one test-tube study found that celery seed extract fought off H. pylori bacteria, which are found in the digestive tract of certain individuals and may lead to stomach ulcers (25, 26). Ultraviolet spectrographic studies have indicated the presence of a compound similar or identical to 8-methoxypsoralen. One tablespoon (6.5 grams) of celery seeds provides 17% and 38% of the RDIs for women and men, respectively. Ann.Allergy 1984;53(6 Pt 2):665-672. A novel compound from celery seed with a bactericidal effect against Helicobacter pylori. One tablespoon (6.5 grams) of the seeds provides 12% of the RDI for this mineral. It has tough, ribbed green stems and segmented dark-green leaves containing toothed leaflets. Strain the seeds from the water and enjoy. Here are five reasons you should consider adding celery to your diet. Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? You should talk with your health care provider for complete information about the risks and benefits of using this product. Here are a few recommendations for celery seed supplements that might be beneficial for gout, although you should speak with your doctor first: Natural Factors There has been no significant increase for me. Bleeding may occur. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Bleeding may occur. See additional information. What Are the Benefits of Celery Seed Tea? Contact Dermatitis 1979;5(3):191. Your body requires a healthy balance of antioxidants and free radicals to maintain optimal health (28). Pregnant women should not use celery seed because it may lead to uterine bleeding and muscle contractions in the uterus, which could cause miscarriage. Though small in size, celery seeds are of great nutritional value and provide many health benefits. Inhibition of hepatic xanthine dehydrogenase and xanthine oxidase was suggested.Dolati 2018, Clinical trials guiding celery dosage are limited. Taking celery root along with medications that also slow blood clotting might increase the risk of bruising and bleeding. Total venlafaxine and metabolite levels were elevated, and serotonin syndrome was ruled out. As a result, you may develop iron-deficiency anemia (15). They have been used as a common treatment for arthritis, gout, menstrual cramps, inflammation and high blood pressure. Eastern medicine has used celery seeds for thousands of years to treat ailments like bronchitis, skin disorders, and the flu (1). Online ahead of print. Polysaccharides and antioxidants like phenolic acids and flavanols found in celery seeds fight oxidative stress and free radical damage. One of the most well-known minerals for bone health is calcium. WebServing Size: 1 capsule 150 mg per serving 60 servings per container capsule size: 1 Product Description Traditionally used to promote joint and GI health Provides antioxidant support Celery seed is not as widely-recognized in modern Western herbal practices, but its use dates back thousands of years in the East. A study by the Journal of Pharmaceutical Biology in 2010 showed how the alkaloids, tannins and flavonoids in celery improve mucus production, which in turn controls gastric acid. Furthermore, celery actively boosts digestion, relieves bloating and treats water retention. Celery seed extract may possess antibacterial properties, although more research is needed to confirm these findings. 1993;19:77-86. Hypolipidemic and antioxidant activity of mountian celery seed essential oils. Grape seed extract may have heart-health benefits. Banerjee S, Sharma R, Kale RK, Rao AR. This article explores Parmesan cheese's nutritional benefits, uses, and potential. Diet plays an important role in many inflammatory conditions, including gout. [Plasma levels of psoralens after celery ingestion]. Celery seeds are nutrient dense and particularly rich in calcium, manganese, and iron. This increased blood flow may lead to Puig, L. and de Moragas, J. M. Enhancement of PUVA phototoxic effects following celery ingestion: cool broth also can burn. Bleeding may occur. However, more research is required to verify this effect of celery in humans. Celery seed extract is linked to 0 conditions and outcomes. Celery Seed Oleoresin is a natural extract derived from the seeds of the celery plant. But if youre experiencing painful symptoms of gout and are interested in exploring alternative treatment options, speak with your doctor for more information. View abstract. Arch.Dermatol. Am J Health Syst Pharm. Mice that were given celery seed extract showed a significant reduction in total cholesterol, triglycerides and low-density lipo-protein cholesterol (x). Here are a few recommendations for celery seed supplements that might be beneficial for gout, although you should speak with your doctor first: You can also try getting more celery into your diet to help reduce the frequency or severity of gout attacks. View abstract. With many different standardizations, the dosages may differ between supplements. Postepy Hig Med Dosw (Online). 3) pygeum. By the Middle Ages, Europeans were cultivating celery. Ahmed B, Alam T, Varshney M, Khan SA. Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. 3-n-butylphthalide and beta-selinene both exhibit anti-inflammatory and antioxidant properties. In fact, one large review associated magnesium-rich diets with an up to 14% reduced risk of diabetes (21, 24). Kidd, J. M., III, Cohen, S. H., Sosman, A. J., and Fink, J. N. Food-dependent exercise-induced anaphylaxis. Celery generally grows to between 0.3 m and 0.6 m in height. WebA recent human study evaluated the efficacy of a standardized extract of celery seed supplying 85 percent 3nB in 30 patients with mild to moderate hypertension. Healthline only shows you brands and products that we stand behind. Paul Pitchford, in his book "Healing with Whole Foods," recommends celery juice combined with lemon juice to treat headaches caused by high blood pressure and excessive heat. Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., and Pitasawat, B. Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes. Springhouse, PA: Springhouse Corp., 1999. 3 Cancer Preventive Activity View abstract. Celery might also make the skin more sensitive to sunlight. Ayurvedic medicine uses celery seed to treat water retention, colds and flu, poor digestion, different types of arthritis and certain diseases of the liver and spleen, according to Penn State Hershey Medical Center. Al-Asmari AK, et al. Clin Exp Allergy 1996;26:1161-70. View abstract. Food Chem.Toxicol. We include products we think are useful for our readers. Oatmeal isnt the best food if you have gout, but it certainly isnt the worst. View abstract. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. Inhibition of cell adhesion, antiangiogenic properties, proapoptosis, and other effects have been demonstrated in studies using human cancer cell lines.Iyer 2019, Kasiri 2018, Kowalczyk 2017, Sung 2016 In vitro and rodent studies suggest essential oil from celery may also possess cytotoxic and antimutagenic properties.Christensen 2006, Hashim 1994, Lim 2013, Zheng 1993, Celery extract has demonstrated vasorelaxant effects on isolated rat aortic rings.Jorge 2013 Celery seed extract exerted hypotensive effects in hypertensive, but not normotensive, rats, possibly due to the n-butylphthalide content.Moghadam 2013, Tang 2017 Limited studies in rodents report improved lipid profiles with celery seed extracts.Abd El-Mageed 2011, Iyer 2011, Iyer 2019, Rouhi-Boroujeni 2015 Additional effects in cardiovascular disease include decreased secretion of proinflammatory cytokines.Tang 2017, Limited clinical studies have been conducted to evaluate the effects of the extracted compound butylphthalide in strokeWang 2018; one study demonstrated superiority of 90-day treatment with dl-3-n-butylphthalide (a synthetic variation of l-3-n-butylphthalide, an extract from seeds of A. graveolens) over aspirin in patients with acute ischemic stroke.Cui 2013 The synthetic version of the compound is clinically approved as an anti-ischemic agent in China.Abdoulaye 2016, In older studies, 3-n-butylphthalide showed sedative and anticonvulsant effects in rodents.Khan 2009 In induced Parkinson disease models in mice, extracts from whole A. graveolens plant improved behavioral performance, oxidative stress parameters, and monoamine oxidase A and B activity.Chonpathompikunlert 2018, Huang 2010 Other studies in rodents report improvements in cognition and depression, and modulation of endogenous antioxidant and neurotransmitter systems.Boonruamkae 2017 Reviews exist regarding neuroprotective effects of the flavone luteolin, which is found in several plant products, including celery.Nabavi 2015, Clinical studies are lacking. View abstract. celery seed extract, fresh or dried seeds, tablets and as capsules filled with celery seed oil. More importantly, celery seeds may be useful in the treatment of hypertension help normalize blood pressure.(x). Clinical trials guiding celery dosage are limited. Despite their small size, celery seeds have an Though small in size, celery seeds are of great nutritional value and provide many health benefits. Maljaei MB, Moosavian SP, Mirmosayyeb O, Rouhani MH, Namjoo I, Bahreini A. Celery seeds consist of the oil (petroselinic, linoleic, palmitic, and oleic fatty acids) and volatile compounds, mostly monoterpene hydrocarbons.Kooti 2017 The major constituents of celery seed oil are d-limonene (60%), selinene (10%), and related phthalides (3%) (eg, 3-n-butylphthalide, sedanenolide, sedanonic anhydride). View abstract. Research has shown that celery seed may be dangerous in pregnant women, as it may cause miscarriage when taken in large doses. View abstract. Adv Orthop. Combined with anise and saffron, celery seed extract is used to treat menstrual discomfort and reduce fluid retention(x). How celery works to combat gout. Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. Celery seeds are likely safe when used as a cooking spice. Studies by the Sheffield Hallam Universitys Biomedical Research Centre in the United Kingdom show that celery seeds have powerful antibacterial components and are effective against H. pylori and other types of bacteria (x). 2018;39(2):154-160. Plus, theyre available in supplemental form.You can find both the spice and celery seed supplements locally or online. Heres the science behind the popular trend. Parasitol.Res 2009;104(3):515-521. Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. In Asian medicine, celery seed is used to treat headaches and as a diuretic, digestive aid, and emmenagogue. It can lead to severe pain, redness and swelling. 2008;63(2):243-4. (2017). Deficiency in either of these nutrients may lead to chronic bone diseases like osteoporosis (11, 12, 13). Use sunscreen or sunblock lotions. Is apple cider vinegar an effective treatment for gout? However, various research studies may give us a starting place for beneficial dosages in humans. WebOf these, 3-n-butylphthalide (3nB) is one of the most well researched. This could make the effects of blood thinners stronger and raise the risk of bleeding. A Root Vegetable With Surprising Benefits, 10 Delicious Herbs and Spices With Powerful Health Benefits, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Parmesan Cheese: Nutrition, Benefits, and Uses. The researchers found that luteolin from celery seeds reduced the production of nitric oxide from uric acid. View abstract. DOI: Bakar FIA, et al. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Refractory gout is diagnosed when your gout flare-ups continue or worsen despite treatment. A new French multicenter study]. Do not use celery seed or apply celery seed oil if you are in the sun for an extended period of time. 2003;41:235-239. A study published in Progress in Drug Research, concluded that celery seed extract could be just as effective at reducing inflammation as aspirin and ibuprofen (x). Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. Fresh celery contains important nutrients but celery seed extract in supplements may cause side effects. Allergy. These seeds have usually been treated with chemicals. Medically reviewed by Drugs.com. Few studies have investigated celery seed, so researchers do not really know whether it interacts with other herbs and medications. Maintaining healthy blood sugar levels is important for reducing your risk of type 2 diabetes and heart disease (19, 20). See additional information. 2012;66:132-4. Celery soup causing severe phototoxicity during PUVA therapy [letter]. Web1) celery seed extract (tried this after using celery seed on its own to no success) 2) sunflower lecithin. There are plenty of celery seed supplements on the market to explore. One study on Varbenaceae, a medicinal herb, examined the antioxidant properties of beta-selinene. If you use celery seed extract, make sure to use sunscreen or sunblock lotions to protect your skin from sunburn. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Am J Clin Nutr. All rights reserved. Celery seeds contain several substances, including: Scientists have not studied celery seeds in children, so it is not recommended for use in children under 18. If you have a history of heart disease, you may want to start with a lower dose of the herb. Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Many delicious ingredients are also exceptionally healthy. Wet and salty soils, swamps, and marshes are the preferred environments for celery. Conventional. Eur.J Drug Metab Pharmacokinet. Studies do show that celery seed acts as a mosquito repellent. Boffa MJ, Gilmour E, Ead RD. Its most active chemical, curcumin, has potent anti-inflammatory and antioxidant properties. Celery (Apium graveolens) is a plant that grows throughout the world. Gout is triggered when uric acid builds up within the joints. 2000;71:575-582. Late in the 19th century, various celery tonics and elixirs appeared commercially, generally containing the juice of crushed celery seeds and often with a large amount of alcohol. Most celery seed studies are either animal studies or in vitro studies, so theres a lack of research exploring celery seed in human dosages. Celery Seed Oleoresin is a natural extract derived from the seeds of the celery plant. Avicenna J Phytomed 2021;11(1):44-53. Thyroid medications: Celery seed may interact with thyroid medications. Ann.Dermatol Venereol 2005;132(6-7 Pt 1):566-567. Laboratory studies have shown celery seed extract contains organic compounds capable preventing the release of pain chemicals. In fact, celery can satisfy hunger since it fills the stomach and is not as calorically dense as other foods. In an Australian study, mice suffering from arthritis and gout took a combination of Indian celery seed extract and New Zealand green-lipped mussels. Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. Liu CY, et al. View abstract. This article covers whether weight loss can help with symptoms of gout and offers advice for managing gout through your diet, exercise routine, and, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. (2017). Celery is POSSIBLY SAFE for most people when taken by mouth or applied to Ciganda C, et al. Theyre particularly rich in various minerals, such as calcium, iron, and manganese. Celery seed has "generally recognized as safe" (GRAS) status when used as a food, according to the US Food and Drug Administration (FDA). Case report. Celery promotes weight loss, helps to detoxify the liver and boosts lipid metabolism since it is rich in electrolytes, antioxidants, and vitamins B and C (x). Pers.Common Name(s): Celery, Celery seed, Celery seed oil. However, certain individuals should avoid supplemental celery seed due to safety concerns, particularly pregnant women.